The Testosterone Blueprint
Women

What are the side effects of HRT?

Most HRT side effects are mild and settle within a few months — things like breast tenderness, bloating, mild nausea, headaches, or spotting as your body adjusts.

When you start HRT, temporary side effects are common as your system settles: tender breasts, bloating or fluid retention, mild nausea, headaches, leg cramps, mood changes, or irregular bleeding and spotting in the first few months. These usually ease, and adjusting the type, dose, or delivery method (for example, switching from tablets to a patch or gel) resolves most persistent ones. Separately, there are small risks to weigh — the specifics depend on the type of HRT, your age, and your health history, which is exactly why it's an individual decision.

It's worth knowing that body-identical, transdermal options (patches and gels) carry a more favourable profile than older oral types for some risks, which your doctor can factor in.

What to do: don't abandon HRT at the first niggle — give it a few months and tell your GP about anything that doesn't settle, since the regimen can usually be tweaked. Report any heavy or unexpected bleeding, severe headaches, or leg swelling promptly. The decision to start, continue, or stop should always be made with your doctor, weighing benefits against your personal risks.

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Based on guidance from the NHS, NICE, Cleveland Clinic and peer-reviewed research.
By M. Videika, author of The Testosterone Blueprint · Reviewed June 2026
General information, not a substitute for personal medical advice — always consult your doctor or a qualified health professional before making health decisions.