The "forever chemicals" behind non-stick and water-resistant coatings. They build up because the body clears them very slowly.
PFAS (per- and polyfluoroalkyl substances) are a large group of chemicals prized for repelling water, grease and heat. They are nicknamed "forever chemicals" because the bonds that make them useful also make them extremely slow to break down, both in the environment and in the body, so they accumulate over years rather than clearing in days.
In the home, the classic source is non-stick cookware (PTFE coatings), especially older or scratched pans where the coating is breaking down. PFAS are also used on stain- and water-resistant fabrics, some waterproof clothing, grease-resistant food packaging such as fast-food wrappers and microwave popcorn bags, and they can appear in drinking water in some areas.
PFAS are among the most closely regulated of these chemicals. Human studies have linked higher levels with thyroid changes, raised cholesterol, altered immune response and effects on fertility and birth weight, and bodies including the US NIEHS and European regulators treat them as a serious concern. The EU is pursuing a broad restriction and the US has set drinking-water limits. Because they persist, the sensible strategy is to reduce the sources you can control rather than expecting quick changes in your own levels.
Beyond that: choose "PFAS-free" or "PFOA-free" labelled products where available, be cautious with stain-repellent treatments on furniture and clothing, and, if you are in an area with known water contamination, a certified filter (activated carbon or reverse osmosis) can help.
You cannot avoid PFAS completely, since they are widespread. But swapping worn non-stick pans and reducing grease-proof packaging removes two of the most direct household sources, and that is a reasonable, proportionate response.
Sources: US NIEHS, US Environmental Protection Agency, European Chemicals Agency (ECHA). Written by M. Videika, The Hormone Blueprint. Educational only, not a substitute for medical advice.